indication-dossier

1# Indication Dossier
2 
3Produces a structured research dossier on a single indication, framed as a
4patient population: who they are, what's wrong, how they're treated today,
5and how clinical trials can be designed to help them. Runs as five phases
6that write resumable waypoint files; after a brief identity check at the end
7of Phase 1, the remaining phases run straight through.
8 
9## Framing
10 
11**Think of an indication as a patient population.** Frame everything
12from the patient perspective: "Who are these patients?" not "What is this
13disease?"; "How are these patients identified and managed?" not "What causes
14this condition?"; population nesting: "all patients in {child} are patients
15in {parent}".
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17Some indications don't map to ICD codes or standard disease definitions:
18"immunosenescence" is a biological state, not a billable diagnosis; "ageing"
19is not an FDA-accepted indication; "GLP-1 induced sarcopenia" is an
20iatrogenic population. Note these distinctions explicitly. They matter for
21regulatory path and trial design.
22 
23## Inputs
24 
25- **`indication`** (required) — indication name (e.g., "sarcopenia",
26  "idiopathic pulmonary fibrosis").
27- **`additional_context`** (optional) — areas to focus on, parent
28  indication, or other framing.
29- **`workdir`** (optional) — where to write waypoints and the final report.
30  Defaults to `./do_not_commit/indication-dossier-<slug>/`.
31 
32## Tools this skill expects
33…