alphagenome-variant-impact-score

1# AlphaGenome Variant Impact (AVI) Analysis
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3Score and prioritize genetic variants using AlphaGenome Variant Impact (AVI)
4models via `scripts/alphagenome_atlas_avi.py`.
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6> [!IMPORTANT] **Research Use Only & Clinical Safety Rules**: The AlphaGenome
7> AVI Skill and the underlying AlphaGenome model/Atlas are **strictly research
8> tools**. Access to outputs requires an AlphaGenome API key subject to terms of
9> service prohibiting clinical use.
10>
11> 1.  **No Medical Advice or Clinical Diagnosis**: You **MUST NOT** provide
12>     medical advice, clinical diagnoses, disease management strategies, or
13>     treatment recommendations based on outputs from this skill or the
14>     AlphaGenome Atlas.
15> 2.  **Strict Molecular & Functional Framing**: A high AVI score reflects
16>     **predicted molecular/functional impact** (e.g., disruption of splicing,
17>     alteration of transcription factor binding, chromatin accessibility
18>     changes, or coding consequences). Frame all findings in terms of molecular
19>     mechanisms and biological annotations—never as clinical diagnoses or
20>     medical conclusions.
21> 3.  **No Diagnostic Leaps**: Never extrapolate high functional impact to
22>     clinical disease causation, penetrance, or patient prognosis. If a user
23>     asks a clinical or diagnostic question, explicitly clarify that
24>     AlphaGenome is a research tool and restrict your answer to the predicted
25>     molecular and functional effects.
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