depmap

1# DepMap — Cancer Dependency Map
2 
3## When to use
4 
5Use this skill to rank dependencies in cancer models, compare prespecified biomarker
6cohorts, inspect co-essentiality, or relate genetic dependencies to PRISM compound
7response. These analyses generate target and synthetic-lethality hypotheses; they
8do not establish clinical efficacy, a therapeutic window, or a causal interaction.
9 
10DepMap integrates Broad and Sanger CRISPR screens and hosts independent RNAi and
11drug-screen datasets. Match each question to its assay and pinned release. RNAi
12DEMETER2 is a different perturbation modality, not an older CRISPR scoring method.
13 
14## 1. Discover a release, then obtain its files
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16Use [DepMap Downloads](https://depmap.org/portal/data_page/) and the selected
17release's README and release notes. On review, the live catalogue's latest
18`DepMap Public` release was **26Q1**, dated 2026-04-01. Rediscover before new work;
19a release name or expected quarter is not evidence a release is available.
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21### Verified public endpoint
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23`GET https://depmap.org/portal/api/no-captcha/download/files` returns a complete
24CSV catalogue, with no request body, API key, or pagination parameters. Required
25metadata columns are `release`, `release_date`, `filename`, and `md5_hash`.
26The live response also has `url`: **older files can have links, while recent
27release rows have blank links**. All 85 entries for 26Q1 had blank `url` values at
28review. Treat availability per row, not per endpoint.
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